Université d'Auvergne Clermont1 | CNRS


Serial optical coherence tomography imaging of ACS-causing culprit plaques.

TitleSerial optical coherence tomography imaging of ACS-causing culprit plaques.
Publication TypeJournal Article
Year of Publication2015
AuthorsSouteyrand, G., E. Arbustini, P. Motreff, L. Gatto, L. Di Vito, V. Marco, N. Amabile, A. Chisari, T. Kodama, E. Romagnoli, L. Tavazzi, F. Crea, J. Narula, and F. Prati
JournalEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Date Published2015 Jul 22

AIMS: The aim of this study was to understand better the mechanisms of repair of plaque complications causing acute coronary syndrome.

METHODS AND RESULTS: We used OCT in the acute phase and at follow-up (one to seven months) to investigate the plaque healing in 10 culprit plaques: five ruptured fibrous cap (RFC) and five intact fibrous cap (IFC) which were not treated with stent deployment and caused ST-segment elevation myocardial infarction (n=8) and non-STEMI (n=2). At follow-up OCT, the margins of the evacuated cavity in RFC plaques showed a smooth surface and a morphology similar to that of baseline images, while IFC plaques showed a smoothened intimal border and a double layering indicating organising thrombus incorporated in the superficial layers of the plaque.

CONCLUSIONS: In the months following a successfully dissolved acute thrombosis, OCT revealed that the cavity of RFC plaques persists and is bordered by a smooth "neointima", while IFC plaques showed features suggesting partial incorporation of the deepest layers of thrombus in the plaque.

Alternate JournalEuroIntervention