Serial optical coherence tomography imaging of ACS-causing culprit plaques.
|Title||Serial optical coherence tomography imaging of ACS-causing culprit plaques.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Souteyrand, G., E. Arbustini, P. Motreff, L. Gatto, L. Di Vito, V. Marco, N. Amabile, A. Chisari, T. Kodama, E. Romagnoli, L. Tavazzi, F. Crea, J. Narula, and F. Prati|
|Journal||EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology|
|Date Published||2015 Jul 22|
AIMS: The aim of this study was to understand better the mechanisms of repair of plaque complications causing acute coronary syndrome.
METHODS AND RESULTS: We used OCT in the acute phase and at follow-up (one to seven months) to investigate the plaque healing in 10 culprit plaques: five ruptured fibrous cap (RFC) and five intact fibrous cap (IFC) which were not treated with stent deployment and caused ST-segment elevation myocardial infarction (n=8) and non-STEMI (n=2). At follow-up OCT, the margins of the evacuated cavity in RFC plaques showed a smooth surface and a morphology similar to that of baseline images, while IFC plaques showed a smoothened intimal border and a double layering indicating organising thrombus incorporated in the superficial layers of the plaque.
CONCLUSIONS: In the months following a successfully dissolved acute thrombosis, OCT revealed that the cavity of RFC plaques persists and is bordered by a smooth "neointima", while IFC plaques showed features suggesting partial incorporation of the deepest layers of thrombus in the plaque.